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Copper coordination may be affected by pH, ionic strength, and chelating agents

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Naturally occurring bioactive compounds, including flavonoids, terpenoids, polysaccharides and coumarin derivatives, all of which have been previously demonstrated to exhibit antioxidant and anti-inflammatory properties, are now becoming increasing recognized to possess anti-melanogenesis functions (44,45)

Abstract Objectives: Despite the various treatment approaches proposed for major depressive disorder (MDD), the right treatment protocol for different patients is not the same